The Antioxidant Selenoprotein T Mimetic, PSELT, Induces Preconditioning-like Myocardial Protection by Relieving Endoplasmic-Reticulum Stress

• Main Authors: Carmine Rocca (Author), Anna De Bartolo (Author), Maria Concetta Granieri (Author), Vittoria Rago (Author), Daniela Amelio (Author), Flavia Falbo (Author), Rocco Malivindi (Author), Rosa Mazza (Author), Maria Carmela Cerra (Author), Loubna Boukhzar (Author), Benjamin Lefranc (Author), Jérôme Leprince (Author), Youssef Anouar (Author), Tommaso Angelone (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress and endoplasmic reticulum stress (ERS) are strictly involved in myocardial ischemia/reperfusion (MI/R). Selenoprotein T (SELENOT), a vital thioredoxin-like selenoprotein, is crucial for ER homeostasis and cardiomyocyte differentiation and protection, likely acting as a redox-sensing...