Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson's Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway

• Main Authors: Ru-Huei Fu (Author), Chia-Wen Tsai (Author), Shih-Ping Liu (Author), Shao-Chih Chiu (Author), Yen-Chuan Chen (Author), Yu-Ting Chiang (Author), Yun-Hua Kuo (Author), Woei-Cherng Shyu (Author), Shinn-Zong Lin (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We assessed the antioxidant potential of narcissoside from <i>Sambucus nigra</i> flowers (elderflowers) in Parkinson's disease models in vitro and in vivo. The results showed that narcissoside lessened the 6-hydroxydopamine (6-OHDA)-induced increase in reactive oxygen species (ROS)...