Adenosine A2A-Receptor Stimulation Inhibits Lipopolysaccharide-Induced Interleukin-18 Production in Monocytes

• Main Authors: Hideo Kohka Takahashi (Author), Toru Kanke (Author), Keyue Liu (Author), Tadashi Yoshino (Author), Toshiaki Sendo (Author), Noriaki Tanaka (Author), Masahiro Nishibori (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine inhibited interleukin (IL)-18 production in lipopolysaccharide (LPS)-stimulated monocytes. The action of adenosine was antagonized by an adenosine A2A-receptor (A2AR) antagonist and was mimicked by an A2AR agonist, suggesting that the stimulation of A2AR may be involved in the actions of a...