Validation of a UHPLC-MS/MS Method to Quantify Twelve Antiretroviral Drugs within Peripheral Blood Mononuclear Cells from People Living with HIV

• Main Authors: Amedeo De Nicolò (Author), Alice Ianniello (Author), Micol Ferrara (Author), Valeria Avataneo (Author), Jessica Cusato (Author), Miriam Antonucci (Author), Elisa De Vivo (Author), Catriona Waitt (Author), Andrea Calcagno (Author), Alice Trentalange (Author), Giampiero Muccioli (Author), Stefano Bonora (Author), Giovanni Di Perri (Author), Antonio D'Avolio (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, anti-HIV treatment has achieved high efficacy and tolerability. Nevertheless, few data are available about the intracellular penetration of antiretrovirals, partly due to the technical challenges related to intracellular quantification. This work aimed to validate an ultra-high performance...