Virtual clinical trial simulations for a novel KRASG12C inhibitor (ASP2453) in non‐small cell lung cancer

• मुख्य लेखकों: Hiroyuki Sayama (लेखक), Diana Marcantonio (लेखक), Takeyuki Nagashima (लेखक), Masashi Shimazaki (लेखक), Tsuyoshi Minematsu (लेखक), Joshua F Apgar (लेखक), John M. Burke (लेखक), Lucia Wille (लेखक), Yasuhisa Nagasaka (लेखक), Daniel C. Kirouac (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2021-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract KRAS is a small GTPase family protein that relays extracellular growth signals to cell nucleus. KRASG12C mutations lead to constitutive proliferation signaling and are prevalent across human cancers. ASP2453 is a novel, highly potent, and selective inhibitor of KRASG12C. Although preclinica...