Naphthoquinone amino acid derivatives, synthesis and biological activity as proteasome inhibitors

• Main Authors: Mauro Marastoni (Author), Claudio Trapella (Author), Alessandra Scotti (Author), Anna Fantinati (Author), Valeria Ferretti (Author), Erika Marzola (Author), Gallerani Eleonora (Author), Riccardo Gavioli (Author), Delia Preti (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The ubiquitin-proteasome system has been largely investigated for its key role in protein degradation mechanisms that regulate both apoptosis and cell division. Because of their antitumour activity, different classes of proteasome inhibitors have been identified to date. Some of these compounds are...