Pharmacokinetics of recombinant human annexin A5 (SY-005) in patients with severe COVID-19

• Main Authors: Brent J. Tschirhart (Author), Xiangru Lu (Author), Aristide Laurel Mokale Kognou (Author), Claudio M. Martin (Author), Marat Slessarev (Author), Douglas D. Fraser (Author), Aleksandra Leligdowicz (Author), Bradley Urquhart (Author), Qingping Feng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Annexin A5 is a phosphatidylserine binding protein with anti-inflammatory, anticoagulant and anti-apoptotic properties. Preclinical studies have shown that annexin A5 inhibits pro-inflammatory responses and improves organ function and survival in rodent models of sepsis. This clinical tri...