Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative

• Main Authors: Samaa Alrushaid (Author), Casey L. Sayre (Author), Jaime A. Yáñez (Author), M. Laird Forrest (Author), Sanjeewa N. Senadheera (Author), Frank J. Burczynski (Author), Raimar Löbenberg (Author), Neal M. Davies (Author)
• Format: Book
• Published: MDPI AG, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox's bioavailability and tolerability. The purpose of this study was to characte...