Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative

• Главные авторы: Samaa Alrushaid (Автор), Casey L. Sayre (Автор), Jaime A. Yáñez (Автор), M. Laird Forrest (Автор), Sanjeewa N. Senadheera (Автор), Frank J. Burczynski (Автор), Raimar Löbenberg (Автор), Neal M. Davies (Автор)
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• Опубликовано: MDPI AG, 2017-09-01T00:00:00Z.
• Предметы: article
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Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox's bioavailability and tolerability. The purpose of this study was to characte...