In vitro toxic evaluation of two gliptins and their main impurities of synthesis

• Main Authors: Camila F. A. Giordani (Author), Sarah Campanharo (Author), Nathalie R. Wingert (Author), Lívia M. Bueno (Author), Joanna W. Manoel (Author), Barbara Costa (Author), Shanda Cattani (Author), Marcelo Dutra Arbo (Author), Solange Cristina Garcia (Author), Cássia Virginia Garcia (Author), Nádia Maria Volpato (Author), Elfrides Eva Scherman Schapoval (Author), Martin Steppe (Author)
• Format: Book
• Published: BMC, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The presence of impurities in some drugs may compromise the safety and efficacy of the patient's treatment. Therefore, establishing of the biological safety of the impurities is essential. Diabetic patients are predisposed to tissue damage due to an increased oxidative stres...