Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes.

• Main Authors: Anthony Ford (Author), Daniel Kepple (Author), Beka Raya Abagero (Author), Jordan Connors (Author), Richard Pearson (Author), Sarah Auburn (Author), Sisay Getachew (Author), Colby Ford (Author), Karthigayan Gunalan (Author), Louis H Miller (Author), Daniel A Janies (Author), Julian C Rayner (Author), Guiyun Yan (Author), Delenasaw Yewhalaw (Author), Eugenia Lo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes, and the majority of Africans are Duffy negative. Recently, there has been a dramatic increase in the re...