Formulation of ciprofloxacin-loaded oral self-emulsifying drug delivery system to improve the pharmacokinetics and antibacterial activity

• Main Authors: Asghar Ali Asghar (Author), Muhammad Akhlaq (Author), Aamir Jalil (Author), Abul Kalam Azad (Author), Junaid Asghar (Author), Muhammad Adeel (Author), Ghadeer M. Albadrani (Author), Amin A. Al-Doaiss (Author), Mohamed Kamel (Author), Ahmed E. Altyar (Author), Mohamed M. Abdel-Daim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aims to increase the aqueous solubility of ciprofloxacin (CPN) to improve oral bioavailability. This was carried out by formulating a stable formulation of the Self-Emulsifying Drug Delivery System (SEDDS) using various ratios of lipid/oil, surfactant, and co-surfactant. A pseudo-ternary...