Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug‐induced heart rate changes

• Главные авторы: Logan Brooks (Автор), Michael Dolton (Автор), Jurgen Langenhorst (Автор), Kenta Yoshida (Автор), Yi Ting (Kayla) (Автор), Vikram Malhi (Автор), Chunze Li (Автор), Pablo Perez‐Moreno (Автор), John Bond (Автор), Ya‐Chi Chen (Автор), Jiajie Yu (Автор)
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• Опубликовано: Wiley, 2023-05-01T00:00:00Z.
• Предметы: article
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Abstract Concentration‐QTc (C‐QTc) analysis has become a common approach for evaluating proarrhythmic risk and delayed cardiac repolarization of oncology drug candidates. Significant heart rate (HR) change has been associated with certain classes of oncology drugs and can result in over‐ or underest...