Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug‐induced heart rate changes

• Main Authors: Logan Brooks (Author), Michael Dolton (Author), Jurgen Langenhorst (Author), Kenta Yoshida (Author), Yi Ting (Kayla) (Author), Vikram Malhi (Author), Chunze Li (Author), Pablo Perez‐Moreno (Author), John Bond (Author), Ya‐Chi Chen (Author), Jiajie Yu (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Concentration‐QTc (C‐QTc) analysis has become a common approach for evaluating proarrhythmic risk and delayed cardiac repolarization of oncology drug candidates. Significant heart rate (HR) change has been associated with certain classes of oncology drugs and can result in over‐ or underest...