Effect of Renal Impairment on the Pharmacokinetics of Memantine

• Main Authors: Takashi Moritoyo (Author), Tomoko Hasunuma (Author), Kazuhiro Harada (Author), Tomonori Tateishi (Author), Makoto Watanabe (Author), Tsutomu Kotegawa (Author), Masahiro Nagai (Author), Yuji Kumagai (Author), Tomomichi Fujitani (Author), Takahumi Okura (Author), Tomikazu Fukuoka (Author), Kenichi Miyoshi (Author), Bunzo Matsuura (Author), Shinya Furukawa (Author), Tomoe Kobori (Author), Hiroyoko Moritoyo (Author), Noriko Nishikawa (Author), Tomoaki Tsujii (Author), Hirotaka Iwaki (Author), Masahiko Nakamura (Author), Satoshi Makino (Author), Kei Ohnuma (Author), Koichiro Yuji (Author), Megumi Hashimoto (Author), Masaru Takasu (Author), Yutaka Hashizume (Author), Koji You (Author), Tomoko Matsumura (Author), Yuji Tanaka (Author), Nahoko Matsumoto (Author), Junichi Nakamura (Author), Jun Miura (Author), Tadao Akizawa (Author), Kozo Kitazawa (Author), Takanori Shibata (Author), Aki Kuroki (Author), Hirokazu Honda (Author), Masanori Mukai (Author), Kyoichi Ohashi (Author), Takuya Morimoto (Author), Hiromitsu Imai (Author), Toshiaki Okudaira (Author), Fuminori Sato (Author), Junko Imanaga (Author), Katsuhiro Tanaka (Author), Masahiro Nomoto (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL/min, n = 6), and mild (50 to ≤ 80 mL/min, n =...