Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation

• Автори: Megan M. Simonds (Автор), Amanda R. Schlefman (Автор), Suzanne M. McCahan (Автор), Kathleen E. Sullivan (Автор), Carlos D. Rose (Автор), AnneMarie C. Brescia (Автор)
• Формат: Книга
• Опубліковано: BMC, 2020-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background To examine critical interactions between juvenile idiopathic arthritis synovial fibroblasts (JFLS) and chondrocytes (Ch), and their role in bony overgrowth seen in patients with juvenile idiopathic arthritis (JIA). Methods Control (CFLS) and JFLS were cultured in synoviocyte medi...