Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle

• Main Authors: Jun Peng (Author), Liming Yu (Author), Linzhang Huang (Author), Vivian A. Paschoal (Author), Haiyan Chu (Author), Camila O. de Souza (Author), Joseph V. Varre (Author), Da Young Oh (Author), Jennifer J. Kohler (Author), Xue Xiao (Author), Lin Xu (Author), William L. Holland (Author), Philip W. Shaul (Author), Chieko Mineo (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Sialic acid is a terminal monosaccharide of glycans in glycoproteins and glycolipids, and its derivation from glucose is regulated by the rate-limiting enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). Although the glycans on key endogenous hepatic proteins governing glucose metabolism a...