Application of Physiologically‐Based Pharmacokinetic Modeling to Predict Gastric pH‐Dependent Drug-Drug Interactions for Weak Base Drugs

Application of Physiologically‐Based Pharmacokinetic Modeling to Predict Gastric pH‐Dependent Drug-Drug Interactions for Weak Base Drugs

Weak‐base drugs are susceptible to drug-drug interactions (DDIs) when coadministered with gastric acid-reducing agents (ARAs). We developed PBPK models to evaluate the potential of such pH‐dependent DDIs for four weak‐base drugs, i.e., tapentadol, darunavir, erlotinib, and saxagliptin. The physiolog...

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Main Authors: Zhongqi Dong (Author), Jia Li (Author), Fang Wu (Author), Ping Zhao (Author), Sue‐Chih Lee (Author), Lillian Zhang (Author), Paul Seo (Author), Lei Zhang (Author)
Format: Book
Published: Wiley, 2020-08-01T00:00:00Z.
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