Application of Physiologically‐Based Pharmacokinetic Modeling to Predict Gastric pH‐Dependent Drug-Drug Interactions for Weak Base Drugs

• Egile Nagusiak: Zhongqi Dong (Egilea), Jia Li (Egilea), Fang Wu (Egilea), Ping Zhao (Egilea), Sue‐Chih Lee (Egilea), Lillian Zhang (Egilea), Paul Seo (Egilea), Lei Zhang (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2020-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Weak‐base drugs are susceptible to drug-drug interactions (DDIs) when coadministered with gastric acid-reducing agents (ARAs). We developed PBPK models to evaluate the potential of such pH‐dependent DDIs for four weak‐base drugs, i.e., tapentadol, darunavir, erlotinib, and saxagliptin. The physiolog...