A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy

• Main Authors: Qianhua Feng (Author), Yutong Hao (Author), Shuaiqi Yang (Author), Xiaomin Yuan (Author), Jing Chen (Author), Yuying Mei (Author), Lanlan Liu (Author), Junbiao Chang (Author), Zhenzhong Zhang (Author), Lei Wang (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The typical hallmark of tumor evolution is metabolic dysregulation. In addition to secreting immunoregulatory metabolites, tumor cells and various immune cells display different metabolic pathways and plasticity. Harnessing the metabolic differences to reduce the tumor and immunosuppressive cells wh...