Proteinase-Activated Receptor-2-Triggered Prostaglandin E2 Release, but Not Cyclooxygenase-2 Upregulation, Requires Activation of the Phosphatidylinositol 3-Kinase / Akt / Nuclear Factor-κB Pathway in Human Alveolar Epithelial Cells

Proteinase-Activated Receptor-2-Triggered Prostaglandin E2 Release, but Not Cyclooxygenase-2 Upregulation, Requires Activation of the Phosphatidylinositol 3-Kinase / Akt / Nuclear Factor-κB Pathway in Human Alveolar Epithelial Cells

Proteinase-activated receptor-2 (PAR2) triggers upregulation of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) formation in human alveolar epithelial A549 cells. This COX-2 upregulation appears to involve the Src / epidermal growth factor (EGF) receptor / p38 MAP kinase (p38MAPK) pathway and a...

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Main Authors: Kazumi Moriyuki (Author), Fumiko Sekiguchi (Author), Kaori Matsubara (Author), Hiroyuki Nishikawa (Author), Atsufumi Kawabata (Author)
Format: Book
Published: Elsevier, 2009-01-01T00:00:00Z.
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