GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats

• Главные авторы: Bo Hu (Автор), Yuhong Wu (Автор), Jie Liu (Автор), Xiaohua Shen (Автор), Fei Tong (Автор), Guangtao Xu (Автор), Ruilin Shen (Автор)
• Формат: ‌
• Опубликовано: Karger Publishers, 2016-12-01T00:00:00Z.
• Предметы: article
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Background/Aims: Diabetes mellitus (DM) can lead to renal damage and dysfunction, and exacerbate renal ischemia/reperfusion injury (RI/RI). The aim of this study was to investigate the protective effect of GSK-3β inhibitor TDZD-8 against RI/RI through Nrf2/TrxR2 signaling pathway in a rat DM model....