GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats

• Main Authors: Bo Hu (Author), Yuhong Wu (Author), Jie Liu (Author), Xiaohua Shen (Author), Fei Tong (Author), Guangtao Xu (Author), Ruilin Shen (Author)
• Format: Book
• Published: Karger Publishers, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Diabetes mellitus (DM) can lead to renal damage and dysfunction, and exacerbate renal ischemia/reperfusion injury (RI/RI). The aim of this study was to investigate the protective effect of GSK-3β inhibitor TDZD-8 against RI/RI through Nrf2/TrxR2 signaling pathway in a rat DM model....