Exploring the sequence diversity and surface expression of Factor H-Binding Protein among invasive serogroup B meningococcal strains from selected European countries

• Main Authors: Stephen A. Clark (Author), Laura Willerton (Author), Heike Claus (Author), Anna Carannante (Author), Paola Stefanelli (Author), Raquel Abad (Author), Julio A. Vázquez (Author), Ray Borrow (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Factor H-Binding Protein (fHbp) is a key component of meningococcal vaccines such as MenB-fHbp, licensed in the EU, UK, and other countries. Sufficient expression of fHbp on the bacterial surface is necessary for vaccine-induced antibodies to bind and exert bactericidal activity. The flow cytometric...