Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material

• Egile Nagusiak: Hiroki Tanaka (Egilea), Nae Takata (Egilea), Yu Sakurai (Egilea), Tokuyuki Yoshida (Egilea), Takao Inoue (Egilea), Shinya Tamagawa (Egilea), Yuta Nakai (Egilea), Kota Tange (Egilea), Hiroki Yoshioka (Egilea), Masatoshi Maeki (Egilea), Manabu Tokeshi (Egilea), Hidetaka Akita (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The world-first success of lipid nanoparticle (LNP)-based siRNA therapeutics (ONPATTRO^®) promises to accelerate developments in siRNA therapeutics/gene therapy using LNP-type drug delivery systems (DDS). In this study, we explore the optimal composition of an LNP containing a...