TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned

• Asıl Yazarlar: Liuh Ling Goh (Yazar), Chia Wei Lim (Yazar), Khai Pang Leong (Yazar), Kiat Hoe Ong (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Variants in thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) are associated with an accumulation of cytotoxic metabolites leading to increased risk of drug-related toxicity with standard doses of thiopurine drugs. We established TPMT and NUDT15 genetic testing for clinical use and...