TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned
Variants in thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) are associated with an accumulation of cytotoxic metabolites leading to increased risk of drug-related toxicity with standard doses of thiopurine drugs. We established TPMT and NUDT15 genetic testing for clinical use and...
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| Main Authors: | , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2022-09-01T00:00:00Z.
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