Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

• Главные авторы: Chen-Yue Liu (Автор), Jian-Bei Chen (Автор), Yue-Yun Liu (Автор), Xue-Ming Zhou (Автор), Man Zhang (Автор), You-Ming Jiang (Автор), Qing-Yu Ma (Автор), Zhe Xue (Автор), Zong-Yao Zhao (Автор), Xiao-Juan Li (Автор), Jia-Xu Chen (Автор)
• Формат: ‌
• Опубликовано: BMC, 2022-05-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract Background Many studies about depression have focused on the dysfunctional synaptic signaling in the hippocampus that drives the pathophysiology of depression. Radix Bupleuri has been used in China for over 2000 years to regulate liver-qi. Extracted from Radix Bupleuri, Saikosaponin D (SSD)...