Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

• Main Authors: Chen-Yue Liu (Author), Jian-Bei Chen (Author), Yue-Yun Liu (Author), Xue-Ming Zhou (Author), Man Zhang (Author), You-Ming Jiang (Author), Qing-Yu Ma (Author), Zhe Xue (Author), Zong-Yao Zhao (Author), Xiao-Juan Li (Author), Jia-Xu Chen (Author)
• Format: Book
• Published: BMC, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Many studies about depression have focused on the dysfunctional synaptic signaling in the hippocampus that drives the pathophysiology of depression. Radix Bupleuri has been used in China for over 2000 years to regulate liver-qi. Extracted from Radix Bupleuri, Saikosaponin D (SSD)...