Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design

• Автори: Joana Magalhães (Автор), Nina Franko (Автор), Giannamaria Annunziato (Автор), Martin Welch (Автор), Stephen K. Dolan (Автор), Agostino Bruno (Автор), Andrea Mozzarelli (Автор), Stefano Armao (Автор), Aigars Jirgensons (Автор), Marco Pieroni (Автор), Gabriele Costantino (Автор), Barbara Campanini (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the genes that codify cysteine biosynthetic enzymes. Therefore, inhibition of cy...