Population genetics of PDE4B (phosphodiesterase‐4B) in neglected Native Americans: Implications for cancer pharmacogenetics

• Main Authors: Rennan Garcias Moreira (Author), Julia Maria Saraiva‐Duarte (Author), Alexandre Costa Pereira (Author), Martha Sosa‐Macias (Author), Carlos Galaviz‐Hernandez (Author), Meddly Lesley Santolalla (Author), Wagner C. S. Magalhães (Author), Camila Zolini (Author), Thiago Peixoto Leal (Author), Zsolt Balázs (Author), Adrián Llerena (Author), Robert H. Gilman (Author), José Geraldo Mill (Author), Victor Borda (Author), Heinner Guio (Author), Timothy D. O'Connor (Author), Eduardo Tarazona‐Santos (Author), Fernanda Rodrigues‐Soares (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract PDE4B (phosphodiesterase‐4B) has an important role in cancer and in pharmacology of some disorders, such as inflammatory diseases. Remarkably in Native Americans, PDE4B variants are associated with acute lymphoblastic leukemia (ALL) relapse, as this gene modulates sensitivity of glucocortic...