Structural Analysis of The OXA-48 Carbapenemase Bound to A "Poor" Carbapenem Substrate, Doripenem

• Egile Nagusiak: Krisztina M. Papp-Wallace (Egilea), Vijay Kumar (Egilea), Elise T. Zeiser (Egilea), Scott A. Becka (Egilea), Focco van den Akker (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2019-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Carbapenem-resistant Enterobacteriaceae are a significant threat to public health, and a major resistance determinant that promotes this phenotype is the production of the OXA-48 carbapenemase. The activity of OXA-48 towards carbapenems is a puzzling phenotype as its hydrolytic activity against dori...