Therapeutic value of voltage-gated sodium channel inhibitors in breast, colorectal and prostate cancer: a systematic review

• Main Authors: Fabiola eMartin (Author), Chiedu eUfodiama (Author), Ian eWatt (Author), Martin eBland (Author), William J Brackenbury (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although survival rates of breast, colon and prostate cancers are improving, deaths from these tumors frequently occur due to metastasis. Voltage-gated Na+ channels (VGSCs) are membrane proteins, which regulate membrane current and cellular migration during nervous system organogenesis. VGSCs are al...