Therapeutic potential of topical administration of acriflavine against hypoxia-inducible factors for corneal fibrosis

• Main Authors: Shuyan Zhu (Author), Huimin Shan (Author), Jianqiao Li (Author), Lijie Pan (Author), Shudan Wang (Author), Jing Zhu (Author), Hui Guo (Author), Fenghua Mi (Author), Xinyi Wu (Author), Jia Yin (Author), Kunpeng Pang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transdifferentiation of keratocytes into fibroblasts or further into myofibroblasts, which produced denser and more disorganized extracellular matrix, is the major cause of corneal fibrosis and scarring, leading to corneal blindness. TGF-β1 is the critical cytokine for the myofibroblast's trans...