Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na⁺ Current Induction and hERG K⁺ Channel Inhibition

• Glavni autori: Seong-Woo Choi (Autor), Ming-Zhe Yin (Autor), Na-Kyeong Park (Autor), Joo-Han Woo (Autor), Sung-Joon Kim (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

4-Oxo-nonenal (4-ONE) is an endogenous lipid peroxidation product that is more reactive than 4-hydroxy-nonenal (4-HNE). We previously reported the arrhythmic potential of 4-HNE by suppression of cardiac human Ether-a-go-go Related Gene (hERG) K⁺ channels with prolonged action...