The Potential Advantage of Targeting Both PD-L1/PD-L2/PD-1 and IL-10-IL-10R Pathways in Acute Myeloid Leukemia

• Main Authors: Laura Jimbu (Author), Oana Mesaros (Author), Alexandra Neaga (Author), Ana Maria Nanut (Author), Ciprian Tomuleasa (Author), Delia Dima (Author), Corina Bocsan (Author), Mihnea Zdrenghea (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor cells promote the suppression of host anti-tumor type 1 T cell responses by various mechanisms, including the upregulation of surface inhibitory molecules such as programmed death ligand (PD-L)-1, and the production of immunosuppressive cytokines such as interleukin-10 (IL-10). There are over...