Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation

• Main Authors: Radoslaw Wojcik (Author), Marek R. Baranowski (Author), Lukasz Markiewicz (Author), Dorota Kubacka (Author), Marcelina Bednarczyk (Author), Natalia Baran (Author), Anna Wojtczak (Author), Pawel J. Sikorski (Author), Joanna Zuberek (Author), Joanna Kowalska (Author), Jacek Jemielity (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dinucleotide analogs of the messenger RNA cap (m⁷GpppN) are useful research tools and have potential applications as translational inhibitors or reagents for modification of in vitro transcribed mRNAs. It has been previously reported that replacing the methyl group at the N7-p...