The role of neuroinflammation in the transition of acute to chronic pain and the opioid-induced hyperalgesia and tolerance

• Main Authors: Marco Echeverria-Villalobos (Author), Victor Tortorici (Author), Beatriz E. Brito (Author), David Ryskamp (Author), Alberto Uribe (Author), Tristan Weaver (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current evidence suggests that activation of glial and immune cells leads to increased production of proinflammatory mediators, creating a neuroinflammatory state. Neuroinflammation has been proven to be a fundamental mechanism in the genesis of acute pain and its transition to neuropathic and chron...