Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development

• Main Authors: K. Rajakumari (Author), K. Aravind (Author), M. Balamugundhan (Author), Manjunathan Jagadeesan (Author), Ambiga Somasundaram (Author), Parthiban Brindha Devi (Author), Pasiyappazham Ramasamy (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA gyrase is a member of the DNA topoisomerase protein family that catalyzes the conversion of different topological forms of DNA into one another. It is the sole enzyme that causes DNA to negatively supercoil. The enzyme is tetrameric with two GyrA ("A'') and two GyrB ("B'...