Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

• Main Authors: Steven Biesmans (Author), Theo F. Meert (Author), Jan A. Bouwknecht (Author), Paul D. Acton (Author), Nima Davoodi (Author), Patrick De Haes (Author), Jacobine Kuijlaars (Author), Xavier Langlois (Author), Liam J. R. Matthews (Author), Luc Ver Donck (Author), Niels Hellings (Author), Rony Nuydens (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that pe...