No relation between docetaxel administration route and high‐grade diarrhea incidence

• Main Authors: Jeroen J. M. A. Hendrikx (Author), Frederik E. Stuurman (Author), Ji‐Ying Song (Author), Vincent A. deWeger (Author), Jurjen S. Lagas (Author), Hilde Rosing (Author), Jos H. Beijnen (Author), Alfred H. Schinkel (Author), Jan H. M. Schellens (Author), Serena Marchetti (Author)
• Format: Book
• Published: Wiley, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Oral administration of docetaxel in combination with the CYP3A4 inhibitor ritonavir is used in clinical trials to improve oral bioavailability of docetaxel. Diarrhea was the most commonly observed and dose‐limiting toxicity. This study combined preclinical and clinical data and investigated...