Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology

• Asıl Yazarlar: Jared Weddell (Yazar), Manoj S. Chiney (Yazar), Sumit Bhatnagar (Yazar), John P. Gibbs (Yazar), Mohamad Shebley (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2021-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Antibody drug conjugates (ADCs) provide targeted delivery of cytotoxic agents directly inside tumor cells. However, many ADCs targeting solid tumors have exhibited limited clinical efficacy, in part, due to insufficient penetration within tumors. To better understand the relationship between ADC tum...