Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP⁵⁺ (BMX-001)

• Main Authors: Sun Up Noh (Author), Jinyeong Lim (Author), Sung-Won Shin (Author), Yeeun Kim (Author), Woong-Yang Park (Author), Ines Batinic-Haberle (Author), Changhoon Choi (Author), Won Park (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Manganese porphyrins reportedly exhibit synergic effects when combined with irradiation. However, an in-depth understanding of intratumoral heterogeneity and immune pathways, as affected by Mn porphyrins, remains limited. Here, we explored the mechanisms underlying immunomodulation of a clinical can...