Neuroprotective Effects of the Anti-cancer Drug Lapatinib Against Epileptic Seizures via Suppressing Glutathione Peroxidase 4-Dependent Ferroptosis

• Main Authors: Ji-Ning Jia (Author), Xi-Xi Yin (Author), Qin Li (Author), Qi-Wen Guan (Author), Nan Yang (Author), Kang-Ni Chen (Author), Hong-Hao Zhou (Author), Xiao-Yuan Mao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epilepsy is a complex neurological disorder characterized by recurrent and unprovoked seizures. Neuronal death process is implicated in the development of repetitive epileptic seizures. Therefore, cell death can be harnessed for ceasing seizures and epileptogenesis. Oxidative stress is regarded as a...