First-Line Use of Vemurafenib to Enable Thyroidectomy and Radioactive Iodine Ablation for BRAF-Positive Metastatic Papillary Thyroid Carcinoma

• Main Authors: Bao D. Dao MD (Author), Ildiko Lingvay MD, MPH, MSCS (Author), Joseph Sailors MD (Author), Michael Landay MD (Author), Gabriel Shapiro MD, FACP (Author)
• Format: Book
• Published: SAGE Publishing, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background . Patients with metastatic or radioactive iodine refractory papillary thyroid carcinoma (PTC) have poor prognosis due to ineffective therapy for this condition beyond surgery and radioactive iodine (RAI or 131 I). BRAF mutation occurs in more than 44% of PCT. Tyrosine kinase inhibitors, t...