IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities

• Main Authors: Xu He (Author), Abdalla Wedn (Author), Jian Wang (Author), Yanlun Gu (Author), Hongjin Liu (Author), Juqi Zhang (Author), Zhiqiang Lin (Author), Renpeng Zhou (Author), Xiaocong Pang (Author), Yimin Cui (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways to defend the host. Recent studies have revealed additional regulatory functions of STING beyond its innate immune-related a...