The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer

• Main Authors: Matthias Piesche (Author), Jessica Roos (Author), Benjamin Kühn (Author), Jasmin Fettel (Author), Nadine Hellmuth (Author), Camilla Brat (Author), Isabelle V. Maucher (Author), Omar Awad (Author), Carmela Matrone (Author), Simon Gabriel Comerma Steffensen (Author), Georg Manolikakes (Author), Ulrike Heinicke (Author), Kai D. Zacharowski (Author), Dieter Steinhilber (Author), Thorsten J. Maier (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore, Mediterranean diets can be a source of NFA. These highly electrophilic fatty acids can undergo Michael addition reaction w...