Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases

• Main Authors: Cristina Pellegrini (Author), Ludovica Cardelli (Author), Marina De Padova (Author), Lucia Di Nardo (Author), Valeria Ciciarelli (Author), Tea Rocco (Author), Gianluca Cipolloni (Author), Marco Clementi (Author), Alessio Cortellini (Author), Alessandra Ventura (Author), Pietro Leocata (Author), Maria Concetta Fargnoli (Author)
• Format: Book
• Published: Medical Journals Sweden, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30 primary melanomas and 39 related metastases, using molecu...