Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression

• Main Authors: Hongli Shan (Author), Ke Li (Author), Duoyi Zhao (Author), Changliang Chi (Author), Qinyuan Tan (Author), Xiaoqing Wang (Author), Jinhai Yu (Author), Meihua Piao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteosarcoma (OS) is a serious primary bone malignant tumor that can easily affect children and adolescents. Chemotherapy is one of the important and feasible clinical treatment strategies for the treatment of OS at present, which is severely limited due to insufficient retention time, poor penetrat...