Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities

• Hauptverfasser: Qinqin Yin (Verfasst von), Weiyi Zhang (Verfasst von), Bowen Ke (Verfasst von), Jin Liu (Verfasst von), Wensheng Zhang (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Background: lidocaine is one of the most commonly used local anesthetics for the treatment of pain and arrhythmia. However, it could cause systemic toxicities when plasma concentration is raised. To reduce lidocaine's toxicity, we designed a hydroxyl derivative of lidocaine (lido-OH), and its l...