Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities

• Автори: Qinqin Yin (Автор), Weiyi Zhang (Автор), Bowen Ke (Автор), Jin Liu (Автор), Wensheng Zhang (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background: lidocaine is one of the most commonly used local anesthetics for the treatment of pain and arrhythmia. However, it could cause systemic toxicities when plasma concentration is raised. To reduce lidocaine's toxicity, we designed a hydroxyl derivative of lidocaine (lido-OH), and its l...