Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy

• Main Authors: Callum McKenzie (Author), Mohamed El-Kholy (Author), Farhaan Parekh (Author), Mathew Robson (Author), Katarina Lamb (Author), Christopher Allen (Author), James Sillibourne (Author), Shaun Cordoba (Author), Simon Thomas (Author), Martin Pule (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy. We screened a library of Fas-TNFR proteins identifying several novel chimeras tha...