Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC

There has been a renewed interest in therapeutic small interfering RNAs (siRNAs) over the past few years. This is particularly the result of successful and efficient delivery of N-acetylgalactosamine (GalNAc)-conjugated siRNAs to the liver. In general, the lead selection process for siRNA drugs is f...

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Main Authors: Babak Basiri (Author), Fang Xie (Author), Bin Wu (Author), Sara C. Humphreys (Author), Julie M. Lade (Author), Mai B. Thayer (Author), Pam Yamaguchi (Author), Monica Florio (Author), Brooke M. Rock (Author)
Format: Book
Published: Elsevier, 2020-09-01T00:00:00Z.
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Call Number: A1234.567
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