Design, synthesis, and evaluation of novel N'-substituted-1-(4-chlorobenzyl)-1H-indol-3-carbohydrazides as antitumor agents

• Main Authors: Le Cong Huan (Author), Duong Tien Anh (Author), Pham-The Hai (Author), Lai Duc Anh (Author), Eun Jae Park (Author), A Young Ji (Author), Jong Soon Kang (Author), Do Thi Mai Dung (Author), Dao Thi Kim Oanh (Author), Truong Thanh Tung (Author), Dinh Thi Thanh Hai (Author), Sang-Bae Han (Author), Nguyen-Hai Nam (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In continuity of our search for novel anticancer agents acting as procaspase activators, we have designed and synthesised two series of (E)-N'-benzylidene-carbohydrazides (4a-m) and (Z)-N'-(2-oxoindolin-3-ylidene)carbohydrazides (5a-g) incorporating 1-(4-chlorobenzyl)-1H-indole core. Bioev...