Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles

• Principais autores: Zhiqiang Deng (Autor), Yu Dong (Autor), Xiaoting Zhou (Autor), Jia-Hong Lu (Autor), Zhenyu Yue (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2022-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Alzheimer's disease (AD) is a prevalent and deleterious neurodegenerative disorder characterized by an irreversible and progressive impairment of cognitive abilities as well as the formation of amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain. By far, the precise mechanism...